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1

ChemInform Abstract: Synthesis, Crystal Structure Determination, and Biological Properties of the DNA-Dependent Protein Kinase (DNA-PK) Inhibitor 3-Cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1H]-2-one (OK-1035).

Martin Stockley, William Clegg, Gabriele Fontana, Bernard T. Golding, Niall Martin, Laurent J. M. Rigoreau, Graeme C. M. Smith, Roger J. Griffin

Journal:

Year:

2002

File:

PDF, 33 KB

2002

2

2,6-Disubstituted Pyran-4-one and Thiopyran-4-one Inhibitors of DNA-Dependent Protein Kinase (DNA-PK).

Jonathan J. Hollick, Bernard T. Golding, Ian R. Hardcastle, Niall Martin, Caroline Richardson, Laurent J. M. Rigoreau, Graeme C. M. Smith, Roger J. Griffin

Journal:

Year:

2003

File:

PDF, 70 KB

2003

3

Identification of a Highly Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor (NU7441) by Screening of Chromenone Libraries.

Justin J. J. Leahy, Bernard T. Golding, Roger J. Griffin, Ian R. Hardcastle, Caroline Richardson, Laurent Rigoreau, Graeme C. M. Smith

Journal:

Year:

2005

File:

PDF, 12 KB

2005

4

Frequency, correlates, and clinical implications of myocardial perfusion after primary angioplasty and stenting, with and without glycoprotein IIb/IIIa inhibition, in acute myocardial infarction

Costantino O. Costantini, Gregg W. Stone, Roxana Mehran, Eve Aymong, Cindy L. Grines, David A. Cox, Thomas Stuckey, Mark Turco, Bernard J. Gersh, James E. Tcheng, Eulogio Garcia, John J. Griffin, Giul

Journal:

Journal of the American College of Cardiology

Year:

2004

Language:

english

File:

PDF, 155 KB

english, 2004

5

Echocardiographic Assessment of Valve Stenosis: EAE/ASE Recommendations for Clinical Practice

Baumgartner, Helmut, Hung, Judy, Bermejo, Javier, Chambers, John B., Evangelista, Arturo, Griffin, Brian P., Iung, Bernard, Otto, Catherine M., Pellikka, Patricia A., QuiÃ±ones, Miguel

Journal:

Journal of the American Society of Echocardiography

Year:

2009

Language:

english

File:

PDF, 3.17 MB

english, 2009

6

Selective Benzopyranone and Pyrimido[2,1- a ]isoquinolin-4-one Inhibitors of DNA-Dependent Protein Kinase: Synthesis, Structure−Activity Studies, and Radiosensitization of a Human Tumor Cell Line in Vitro

Griffin, Roger J., Fontana, Gabriele, Golding, Bernard T., Guiard, Sophie, Hardcastle, Ian R., Leahy, Justin J. J., Martin, Niall, Richardson, Caroline, Rigoreau, Laurent, Stockley, Martin, Smith, Gra

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 312 KB

english, 2005

7

D ESIGNING I NHIBITORS OF C YCLIN -D EPENDENT K INASES

Hardcastle, Ian R., Golding, Bernard T., Griffin, Roger J.

Journal:

Annual Review of Pharmacology

Year:

2002

Language:

english

File:

PDF, 381 KB

english, 2002

8

Searching for Cyclin-Dependent Kinase Inhibitors Using a New Variant of the Cope Elimination

Griffin, Roger J., Henderson, Andrew, Curtin, Nicola J., Echalier, Aude, Endicott, Jane A., Hardcastle, Ian R., Newell, David R., Noble, Martin E. M., Wang, Lan-Zhen, Golding, Bernard T.

Journal:

Journal of the American Chemical Society

Year:

2006

Language:

english

File:

PDF, 98 KB

english, 2006

9

Raman spectroscopic evidence for the existence of cyanide linkage isomers; equlibria of silver complexes in liquid ammonia

Gans, Peter, Gill, J. Bernard, Griffin, Mervyn

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1976

Language:

english

File:

PDF, 236 KB

english, 1976

10

Angry Aggression Among Police Officers

Griffin, Sean P., Bernard, Thomas J.

Journal:

Police Quarterly

Year:

2003

Language:

english

File:

PDF, 92 KB

english, 2003

11

2-O, 3-O-Desulfated Heparin Inhibits Neutrophil Elastase–Induced HMGB-1 Secretion and Airway Inflammation

Griffin, Kathryn L., Fischer, Bernard M., Kummarapurugu, Apparao B., Zheng, Shuo, Kennedy, Thomas P., Rao, Narayanam V., Foster, W. Michael, Voynow, Judith A.

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

2014

Language:

english

File:

PDF, 643 KB

english, 2014

12

Treatment of Bovine Tuberculosis in an Arabian Oryx (Oryx leucoryx)

Frank E. Rietkerk, Frank T. Griffin, Bernard Wood, Saeed M. Mubarak, Edgardo C. Delima, Osama M. Badri, Nick B. Lindsay and Douglas T. Williamson

Journal:

Journal of Zoo and Wildlife Medicine

Year:

1993

Language:

english

File:

PDF, 791 KB

english, 1993

13

Comparison of cross-sectional geometrical properties and bone density of the proximal radius between Saint Bernard and other giant breed dogs

Mejia, Sebastian, Iodence, Ashley, Griffin, Lynn, Withrow, Stephen, Puttlitz, Christian, Salman, Mo, Seguin, Bernard

Journal:

Veterinary Surgery

Year:

2019

Language:

english

File:

PDF, 899 KB

english, 2019

14

Regiospezifische Alkylierung von 6-Chlor- und 2,6-Dichlorpurin an N7 unter Verwendung von Methylcobaloxim als Schutzgruppe

Christine Dalby, Dr. Christine Bleasdale, Prof. Dr. William Clegg, Dr. Mark R. J. Elsegood, Prof. Dr. Bernard T. Golding, Dr. Roger J. Griffin

Journal:

Angewandte Chemie

Year:

1993

File:

PDF, 259 KB

1993

15

Regiospecific Alkylation of 6-Chloropurine and 2,6-Dichloropurine at N7 by Transient Protection of N3/N9 by Methylcobaloxime

Christine Dalby, Dr. Christine Bleasdale, Prof. Dr. William Clegg, Dr. Mark R. J. Elsegood, Prof. Dr. Bernard T. Golding, Dr. Roger J. Griffin

Journal:

Angewandte Chemie International Edition

Year:

1993

Language:

english

File:

PDF, 286 KB

english, 1993

16

Acute toxicity of amine-boranes and related derivatives in mice

Iris H. Hall, David J. Reynolds, J. Chang, Bernard F. Spielvogel, T.S. Griffin, E.L. Docks

Journal:

Archiv der Pharmazie

Year:

1991

Language:

english

File:

PDF, 462 KB

english, 1991

17

ChemInform Abstract: Protecting-Group Strategies for the Synthesis of N4-Substituted and N1,N8-Disubstituted Spermidines, Exemplified by Hirudonine.

Bernard T. Golding, Andrew Mitchinson, William Clegg, Mark R. J. Elsegood, Roger J. Griffin

Journal:

Year:

1999

File:

PDF, 37 KB

1999

18

ChemInform Abstract: Synthesis of 3-Alkoxy- and 3-Alkylamino-2-alkyl-3-arylisoindolinones.

Martin S. Kitching, William Clegg, Mark R. J. Elsegood, Roger J. Griffin, Bernard T. Golding

Journal:

Year:

1999

File:

PDF, 29 KB

1999

19

ChemInform Abstract: Resistance-Modifying Agents. Part 7. 2,6-Disubstituted-4,8-dibenzylaminopyrimido[5,4-d]pyrimidines that Inhibit Nucleoside Transport in the Presence of α1-Acid Glycoprotein (AGP).

Hannah C. Barlow, Karen J. Bowman, Nicola J. Curtin, A. Hilary Calvert, Bernard T. Golding, Bing Huang, Peter J. Loughlin, David R. Newell, Peter G. Smith, Roger J. Griffin

Journal:

Year:

2000

Language:

english

File:

PDF, 41 KB

english, 2000

20

ChemInform Abstract: Controlled Stepwise Conversion of 2,4,6,8-Tetrachloropyrimido[5,4-d]pyrimidine into 2,4,6,8-Tetrasubstituted Pyrimido[5,4-d]pyrimidines.

Julian S. Northen, F. Thomas Boyle, William Clegg, Nicola J. Curtin, Andrew J. Edwards, Roger J. Griffin, Bernard T. Golding

Journal:

Year:

2002

Language:

english

File:

PDF, 35 KB

english, 2002

21

Facilitation of Addition—Elimination Reactions in Pyrimidines and Purines Using Trifluoroacetic Acid in Trifluoroethanol.

Hayley J. Whitfield, Roger J. Griffin, Ian R. Hardcastle, Andrew Henderson, Jerome Meneyrol, Veronique Mesguiche, Kerry L. Sayle, Bernard T. Golding

Journal:

Year:

2004

File:

PDF, 125 KB

2004

22

Detection and quantification of adulteration of durum wheat flour by flour from common wheat using reverse phase HPLC

P Kieran McCarthy, Bernard F Scanlon, Ian D Lumley, Martin Griffin

Journal:

Journal of the Science of Food and Agriculture

Year:

1990

Language:

english

File:

PDF, 1.16 MB

english, 1990

23

Synthesis of a ‘reverse ester’ analogue of 1,2-sn-diglycerides from (S)-1,2-di-O-isoprophylideneglycerol; efficient, stereospecific nucleophilic displacement via a triflate at glycerol C-2

Bernard T Golding, Alice L Griffin, David H Robinson

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 208 KB

english, 1993

24

Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries

Justin J.J. Leahy, Bernard T. Golding, Roger J. Griffin, Ian R. Hardcastle, Caroline Richardson, Laurent Rigoreau, Graeme C.M. Smith

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 278 KB

english, 2004

25

Isoindolinone-based inhibitors of the MDM2–p53 protein–protein interaction

Ian R. Hardcastle, Shafiq U. Ahmed, Helen Atkins, A. Hilary Calvert, Nicola J. Curtin, Gillian Farnie, Bernard T. Golding, Roger J. Griffin, Sabrina Guyenne, Claire Hutton, Per Källblad, Stuart J. Kem

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 221 KB

english, 2005

26

8-Biarylchromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK)

Marine Desage-El Murr, Celine Cano, Bernard T. Golding, Ian R. Hardcastle, Marc Hummersome, Mark Frigerio, Nicola J. Curtin, Keith Menear, Caroline Richardson, Graeme C.M. Smith, Roger J. Griffin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 212 KB

english, 2008

27

Mapping the ATP-binding domain of DNA-dependent protein kinase (DNA-PK) with coumarin- and isocoumarin-derived inhibitors

Sara L. Payne, Sonsoles Rodriguez-Aristegui, Julia Bardos, Céline Cano, Bernard T. Golding, Ian R. Hardcastle, Marcus Peacock, Nahida Parveen, Roger J. Griffin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.13 MB

english, 2010

28

DNA-dependent protein kinase (DNA-PK) inhibitors: Structure–activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain

Kate M. Clapham, Julia Bardos, M. Raymond V. Finlay, Bernard T. Golding, Edward J. Griffen, Roger J. Griffin, Ian R. Hardcastle, Keith A. Menear, Attilla Ting, Paul Turner, Gail L. Young, Céline Cano

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 946 KB

english, 2011

29

Magneto-photoluminescence studies of Zn1−xMnxTe/ZnTe multiple quantum-well and quantum-dot structures

Ivan J. Griffin, Peter J. Klar, Daniel Wolverson, J. John Davies, Bernard Lunn, Duncan E. Ashenford, Torsten Henning

Journal:

Journal of Crystal Growth

Year:

1998

Language:

english

File:

PDF, 410 KB

english, 1998

30

Distinct mucosal and systemic T cell responses to the respiratory pathogen Bordetella pertussis: Suppressed Th1 responses in the lung during infection are associated with modulated costimulatory molecule expression

Peter Mc Guirk, Bernard P. Mahon, Fiona Griffin, Kingston H.G. Mills

Journal:

Immunology Letters

Year:

1997

Language:

english

File:

PDF, 179 KB

english, 1997

31

Resistance-modifying agents. Part 7: 2,6-disubstituted-4,8-dibenzylaminopyrimido[5,4-d]pyrimidines that inhibit nucleoside transport in the presence of α1-acid glycoprotein (AGP)

Hannah C Barlow, Karen J Bowman, Nicola J Curtin, A.Hilary Calvert, Bernard T Golding, Bing Huang, Peter J Loughlin, David R Newell, Peter G Smith, Roger J Griffin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 134 KB

english, 2000

32

Synthesis, crystal structure determination, and biological properties of the DNA-dependent protein kinase (DNA-PK) inhibitor 3-cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1H]-2-one (OK-1035)

Martin Stockley, William Clegg, Gabriele Fontana, Bernard T Golding, Niall Martin, Laurent J.M Rigoreau, Graeme C.M Smith, Roger J Griffin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 150 KB

english, 2001

33

4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2

Veronique Mesguiche, Rachel J Parsons, Christine E Arris, Johanne Bentley, F.Thomas Boyle, Nicola J Curtin, Thomas G Davies, Jane A Endicott, Ashleigh E Gibson, Bernard T Golding, Roger J Griffin, Phi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 236 KB

english, 2003

34

2,6-Disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-Dependent protein kinase (DNA-PK)

Jonathan J. Hollick, Bernard T. Golding, Ian R. Hardcastle, Niall Martin, Caroline Richardson, Laurent J.M. Rigoreau, Graeme C.M. Smith, Roger J. Griffin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 156 KB

english, 2003

35

Recommendations of the NASPE Policy Conference on Pacemaker Programmability and Follow-up

PAUL A. LEVINE, PETER H. BELOTT, MICHAEL BILITCH, BERNARD BOAL, DORIS J.W. ESCHER, SEYMOUR FURMAN, JERRY C. GRIFFIN, ROBERT G. HAUSER, JAMES D. MALONEY, DRYDEN MORSE, HERBERT J. SEMLER

Journal:

Pacing and Clinical Electrophysiology

Year:

1983

Language:

english

File:

PDF, 187 KB

english, 1983

36

Performance of Implantable Cardiac Rhythm Management Devices

MICHAEL BILITCH, PABLO DENES, BERNARD S. GOLDMAN, JAMES D. MALONEY, J. WARREN HARTHORNE, JERRY C. GRIFFIN, SEYMOUR FURMAN, VICTOR PARSONNET

Journal:

Pacing and Clinical Electrophysiology

Year:

1988

Language:

english

File:

PDF, 2.43 MB

english, 1988

37

The Bilitch Report: Performance of Implantable Cardiac Rhythm Management Devices

SEYMOUR FURMAN, VICTOR PARSONNET, BERNARD S. GOLDMAN, PABLO DENES, SUSAN L. SONG, JAMES D. MALONEY, J. WARREN HARTHORNE, JERRY C. GRIFFIN

Journal:

Pacing and Clinical Electrophysiology

Year:

1989

Language:

english

File:

PDF, 2.56 MB

english, 1989

38

Crystal structure of human osteoclast cathepsin K complex with E-64

Zhao, Baoguang, Janson, Cheryl A., Amegadzie, Bernard Y., D'Alessio, Karla, Griffin, Charles, Hanning, Charles R., Jones, Christopher, Kurdyla, Jeff, McQueney, Michael, Qiu, Xiayang

Journal:

Natural Structural Biology

Year:

1997

File:

PDF, 429 KB

1997

39

Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor

Davies, Thomas G., Bentley, Johanne, Arris, Christine E., Boyle, F. Thomas, Curtin, Nicola J., Endicott, Jane A., Gibson, Ashleigh E., Golding, Bernard T., Griffin, Roger J., Hardcastle, Ian R.

Journal:

Natural Structural Biology

Year:

2002

Language:

english

File:

PDF, 1.70 MB

english, 2002

40

Analyzing the turnout-competition link with aggregate cross-sectional data

Bernard Grofman, Christian Collet, Robert Griffin

Journal:

Year:

1998

Language:

english

File:

PDF, 72 KB

english, 1998

41

N2-Substituted O6-Cyclohexylmethylguanine Derivatives: Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2

Hardcastle, Ian R., Arris, Christine E., Bentley, Johanne, Boyle, F. Thomas, Chen, Yuzhu, Curtin, Nicola J., Endicott, Jane A., Gibson, Ashleigh E., Golding, Bernard T., Griffin, Roger J.

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 320 KB

english, 2004

42

Small-Molecule Inhibitors of the MDM2-p53 Protein−Protein Interaction Based on an Isoindolinone Scaffold

Hardcastle, Ian R., Ahmed, Shafiq U., Atkins, Helen, Farnie, Gillian, Golding, Bernard T., Griffin, Roger J., Guyenne, Sabrina, Hutton, Claire, Källblad, Per, Kemp, Stuart J.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 571 KB

english, 2006

43

The Immunology of Bordetella pertussis Infection

Kingston H.G. Mills, Mark Ryan, Peter Mcguirk, Fiona Griffin, Geraldine Murphy, Bernard Mahon

Journal:

Year:

1999

Language:

english

File:

PDF, 44 KB

english, 1999

44

MDM2-p53 protein–protein interaction inhibitors: A-ring substituted isoindolinones

Anna F. Watson, Junfeng Liu, Karim Bennaceur, Catherine J. Drummond, Jane A. Endicott, Bernard T. Golding, Roger J. Griffin, Karen Haggerty, Xiaohong Lu, James M. McDonnell, David R. Newell, Martin E.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 450 KB

english, 2011

45

Resistance-Modifying Agents. 9.1 Synthesis and Biological Properties of Benzimidazole Inhibitors of the DNA Repair Enzyme Poly(ADP-ribose) Polymerase

White, Alex W., Almassy, Robert, Calvert, A. Hilary, Curtin, Nicola J., Griffin, Roger J., Hostomsky, Zdenek, Maegley, Karen, Newell, David R., Srinivasan, Sheila, Golding, Bernard T.

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 315 KB

english, 2000

46

Discrimination of spermidine amino functions by a new protecting group strategy; application to the synthesis of guanidinylated polyamines, including hirudonine

Mitchinson, Andrew, Golding, Bernard T., Griffin, Roger J., O'Sullivan, Mary C.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1994

Language:

english

File:

PDF, 238 KB

english, 1994

47

Performance of programmable pacing systems

Robert Hauser, Ravindra Prabhu, Nenad Belie, Mary Klodnycky, Gary Wilner, Gerald Tinmis, Lynn Edwards, Jerry Griffin, Kenneth Rosen, Andy Davis, Bernard Staller, C.Richard Smith, John Moran, Juan Bico

Journal:

The American Journal of Cardiology

Year:

1982

Language:

english

File:

PDF, 155 KB

english, 1982

48

Preclinical in vitro and in vivo evaluation of the potent and specific cyclin-dependent kinase 2 inhibitor NU6102 and a water soluble prodrug NU6301

Huw D. Thomas, Lan-Zhen Wang, Celine Roche, Johanne Bentley, Yuzhu Cheng, Ian R. Hardcastle, Bernard T. Golding, Roger J. Griffin, Nicola J. Curtin, David R. Newell

Journal:

European Journal of Cancer

Year:

2011

Language:

english

File:

PDF, 665 KB

english, 2011

49

Protecting-group strategies for the synthesis of N 4-substituted and N 1,N 8-disubstituted spermidines, exemplified by hirudonine

Golding, Bernard T., Mitchinson, Andrew, Clegg, William, Elsegood, Mark R. J., Griffin, Roger J.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1999

Language:

english

File:

PDF, 209 KB

english, 1999

50

Nucleoside Transport Inhibitors: Structure−Activity Relationships for Pyrimido[5,4- d ]pyrimidine Derivatives That Potentiate Pemetrexed Cytotoxicity in the Presence of α 1 -Acid Glycoprotein

Saravanan, Kappusamy, Barlow, Hannah C., Barton, Marion, Calvert, A. Hilary, Golding, Bernard T., Newell, David R., Northen, Julian S., Curtin, Nicola J., Thomas, Huw D., Griffin, Roger J.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.48 MB

english, 2011

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